Unmet need in CSU: Physical Symptoms of Urticaria

The physical symptoms of urticaria**

Itchy hives¹

Itchy hives

Redness and slight swelling
Mild to severe itch
Lasts less than 24 hours

Angioedema^1,2

Angioedema

Burning Pain
Usually lasts a few days
Skin swelling locations: Eyelids, lips, tongue, genitals, extremities, mouth mucosa

BE A LIFE CHANGER

71% reduction
in itch with Xolair^®
300 mg vs baseline
at 12 weeks^†‡3

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Treatment guidelines

International
EAACI/GA²LEN/EDF/WAO
guidelines recommend
omalizumab as an add-on
therapy for CSU patients with
an inadequate response to
H1-antihistamine treatment⁵

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*Patient verbatim and profile comes from hypothetical patient for illustrative purpose only

**Pictures courtesy of Prof. Maurer, Prof. Magerl and their patients.

^†Data from ASTERIA II; two other phase III studies (ASTERIA I and GLACIAL) were also conducted to assess efficacy and safety of Xolair® in inadequately controlled CSU patients

^‡Xolair® 300mg vs. baseline at 12 weeks; p<0.001 vs placebo.

References: 1. Zuberbier T et al. Allergy 2014;69(7):868–887. 2. NHS choices website. Angioedema - Symptoms. Available at: http://www.nhs.uk/Conditions/Angioedema/Pages/Symptoms.aspx. Accessed June 2016. 3. Maurer M, et al. N Engl J Med 2013;368:924-935. 4. Guidelines developed by European Academy of Allergy and Clinical Immunology, Global Allergy and Asthma European Network, European Dermatology Forum and the World Allergy Organization. 5. Zuberbier T et al. Allergy 2014; 69:868-887

NP4 code: GLDEIM/IGE025E/0181