Xolair® adverse reactions in severe allergic asthma2
The adverse reactions observed in severe allergic asthma patients include:2
| Infections and infestations | |
| Uncommon | Pharyngitis |
| Rare | Parasitic infection |
| Blood and lymphatic system disorders | |
| Not known | Idiopathic thrombocytopenia, including severe cases |
| Immune system disorders | |
| Rare | Anaphylactic reaction, other serious allergic conditions, anti-omalizumab antibody development |
| Not known | Serum sickness, may include fever and lymphadenopathy |
| Nervous system disorders | |
| Common | Headache† |
| Uncommon | Syncope, paraesthesia, somnolence, dizziness |
| Vascular disorders | |
| Uncommon | Postural hypotension, flushing |
| Respiratory, thoracic and mediastinal disorders | |
| Common | Allergic bronchospasm, coughing |
| Rare | Laryngoedema |
| Not known | Allergic granulomatous vasculitis (i.e Churg-Strauss syndrome) |
| Gastrointestinal disorders | |
| Common | Abdominal pain Upper†† |
| Uncommon | Dyspeptic signs and symptoms, diarrhoes, nausea |
| Skin and subcutaneous tissue disorders | |
| Uncommon | Photosensitivy, urticaria, rash, pruritua |
| Rare | Angioedema |
| Not know | Alopecia |
| Musculoskeketal and connective tissue disorders | |
| Not known | Arthralgia, myalgia, Joint swelling |
| General disorders and administration site conditions | |
| Very common | Pyrexia†† |
| Common | Injection site reactions such as swelling, erythema, pain, pruritus |
| Uncommon | Influenza-like illness, swelling arms, weight increase, fatigue |
†Very common in children 6-<12 years of age.
††In children 6-<12 years years of age.
Frequency categories are defined as: very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000), very rare (<1/10,000)